SPRAVATO® (Esketamine Nasal Spray)
How it works:
Esketamine targets glutamate, a brain chemical involved in mood regulation. It works faster than most traditional antidepressants, with patients often seeing improvement within the first few treatments
What to expect:
- Urine drug screening required prior to treatment
 
- Administered in our clinic under provider supervision 
 
- Patients will be monitored for 2 hours by staff, with intermittent blood pressure checks
 
- Sessions begin as 2 times/week for the first month, then once weekly for the second month, then once every 2 weeks or once monthly for maintenance if recommended based on treatment response 
 
- Due to sedative effects, designated driver is required to and from each appointment 
 
Side effects:
- Dizziness, nausea, sedation, dissociation (feeling detached from reality)
 
- Short-term increase in blood pressure
 
Not recommended in patients with: 
- Active substance use or abuse
 
- Aneurysmal vascular disease (including thoracic and abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation.
 
- History of intracerebral hemorrhage.
 
- History of hypersensitivity to esketamine, ketamine, or related
 
      
      Author
        
                  Pauleana Stevanovski, PA-C